"Gad" tekst pesme

Voyage & nucci lyrics.

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Voyage & Nucci – Gad Lyrics

Gad Lyrics – Voyage & Nucci

(Hej Dalmo) E, uh, a, a

Gradom hoda polugola kad partija Meni leži tama kao tebi svila “Nisam takva”, znam da to je rekla svima A loži je krivina, kaže “Napravi mi sina” A ja sanjô da vozim Lambo novi (Vroom, vroom) Njena guza sva u Fashion Novi (Vroom, vroom) Nije mala, njeni su joj strogi (Vroom, vroom) Čujem, kada smo u sobi Tako slatku, ja odvedem je na stranu Da joj kažem jednu tajnu malu Nekad desi se da jebem dve u danu Jednu u BG-u, ali drugu u Luganu

Woah, nosi moje stvari, ti prelepa si – bani Pokaži mi šta radiš, kad priđem ti (Woah) “Nismo više mali”, to kaže kad smo sami Dok vozi me kô ‘rari, ja kažem joj “Woah”

Ali mene briga što si sam Da si barem tu na dan Da ti priznam da si gad Niko ne zna ono sto ti znaš Zato dođi da mi daš Druge nikad nisam volela Ali mene briga što si sam Da si barem tu na dan Da ti priznam da si gad Niko ne zna ono sto ti znaš Zato dođi da mi daš Druge nikad nisam volela

Gradom hoda polugola, gde si bila? Jaka riba, mala liči na kriminal Dušu kida ona haljine dok skida Na zlo me tera kô dva grama kokaina A da nisi sama, ja to znam, da l’ bi htela da ti dam? Bebo, reci mi šta osećaš (Brrr) Da je pitam “Draga, šta ćeš sad?” Kad ti kažu da sam gad, biće luda noć, predosećam Ova mala razbija Noću kada kukove mi savija Ma nije neka razlika Bebo, sve si lepsa što si starija

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Gad (feat. Nucci)

Gradom hoda polugola kad partija meni lezi tama kao tebi svila nisam takva, znam da to je rekla svima a lozi je krivina kaze, napravi mi sina A ja sanj´o da vozim Lambo novi (vroom, vroom) njena guza sva u fashion novi (vroom, vroom) nije mala, njeni su joj strogi (vroom, vroom)

Cujem, kada smo u sobi tako slatku ja odvedem je na stranu da joj kazem jednu tajnu malu nekad desi se da jebem dve u danu jednu u BG-u, a drugu u Luganu Wooa, nosi moje stvari ti prelepa si, bunny ti pokazi mi sta radis kad pridjem ti wooa Nismo vise mali to kaze, kad smo sami dok vozi me Ferrari ja kazem joj, wooa Ref. 2x Ali, mene briga sto si sam da si barem tu na dan da ti priznam, da si gad Ni´ko ne zna ono sto ti znas zato, dodji da mi das druge nikad nisam volela Gradom hoda polugola, gde si bila jaka riba, mala lici na kriminal dusu kida, ona haljinu dok skida na zlo me tera, k´o dva grama kokaina A da nisi sama, ja to znam da l´ bi htela da ti dam bebo, reci mi sta osecas Da je pitam draga, sta ces sad kad ti kazu da sam gad bice luda noc, predosecam ova mala razbija nocu, kada kukove mi savija ma, nije neka razlika bebo, sve si lepsa, sta si starija Ref. 2x

Hvala Staniša Borović

07.05.2022 - 18:21

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Nucci - Vroom "Ref. Vroom, kad me opije, glumi da je stena vroom, kada se opije nestane i trema vroom, kad me opije, glumi da je stena kukove uvije kad krene Makarena N..."

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Voyage – Gad

Release Date: April 10, 2022

Comments: 0

Enter your name (nickname), more voyage lyrics.

Voyage - Duplo gora | Lirika Tekst iz isječka: Da je čuva grad, znam da za to tata je Od svih loših duplo gora je, kaže tako bolje je A ja noćas ne znam gde sam možda pogrešim Zato daj sve što imaš da

Voyage - Gad | Lirika {Tekst pesme "Gad"} Tekst iz isečka {Nucci} Tako slatku, ja odvedem je na stranu Da joj kažem jednu tajnu malu Nekad desi se da jebem dve

Image of Voyage

Voyage

Voyage biography

The SIRT3 activator ganoderic acid D regulates airway mucin MUC5AC expression via the NRF2/GPX4 pathway

Affiliations.

  • 1 Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China; Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.
  • 2 Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.
  • 3 Department of Anesthesiology, Luzhou People's Hospital, Luzhou, Sichuan Province, China. Electronic address: [email protected].
  • 4 Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China; Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China. Electronic address: [email protected].
  • PMID: 37879430
  • DOI: 10.1016/j.pupt.2023.102262

Purpose: The expression of MUC5AC, a highly prevalent airway mucin, is regulated by stimulatory factors such as oxidative stress. Ganoderic acid D (GAD) activates mitochondrial deacetylase SIRT3. SIRT3 regulates mitochondrial function through deacetylation of mitochondrial proteins, thereby playing a significant role in alleviating oxidative stress-related diseases. Therefore, this study aimed to investigate the mechanisms and rationale underlying the regulation of MUC5AC expression by GAD.

Methods: Human airway epithelial cells (NCI-H292) were exposed to pyocyanin (PCN) to establish an in vitro cell model of airway mucus hypersecretion. The expression of SIRT3, MUC5AC, and NRF2 pathway proteins in cells was assessed. Cellular mitochondrial morphology and oxidative stress markers were analyzed. C57BL/6 mice were induced with Pseudomonas aeruginosa (PA) to establish an in vivo mouse model of airway mucus hypersecretion. The expression of SIRT3 and MUC5AC in the airways was examined. In addition, the differential expression of target genes in the airway epithelial tissues of patients with chronic obstructive pulmonary disease (COPD) was analyzed using publicly available databases.

Results: The results revealed a significant upregulation of MUC5AC expression and a significant downregulation of SIRT3 expression in relation to airway mucus hypersecretion. GAD inhibited the overexpression of MUC5AC in PCN-induced NCI-H292 cells and PA-induced mouse airways by upregulating SIRT3. GAD activated the NRF2/GPX4 pathway and inhibited PCN-induced oxidative stress and mitochondrial morphological changes in NCI-H292 cells. However, ML385 inhibited the regulatory effects of GAD on MUC5AC expression.

Conclusion: The SIRT3 activator GAD downregulated MUC5AC expression, potentially through activation of the NRF2/GPX4 pathway. Accordingly, GAD may be a potential treatment approach for airway mucus hypersecretions.

Keywords: GPX4; Ganoderic acid D; MUC5AC; NRF2; SIRT3.

Copyright © 2023. Published by Elsevier Ltd.

IMAGES

  1. Gad

    voyage gad text

  2. NUCCI X VOYAGE

    voyage gad text

  3. VOYAGE X NUCCI

    voyage gad text

  4. NUCCI x VOYAGE

    voyage gad text

  5. NUCCI VOYAGE

    voyage gad text

  6. NUCCI X VOYAGE

    voyage gad text

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COMMENTS

  1. Voyage & Nucci

    Gad Lyrics: (Hej, Dalmo) / E, uh, a, a / Gradom hoda polugola kad partija / Meni leži tama kao tebi svila / "Nisam takva", znam da to je rekla svima / A loži je krivina, kaže "Napravi mi sina

  2. Voyage

    Woah, she's wearing my stuff, you're beautiful, come over. Show me what you can do, when I come close (Woah) We are no longer little, she says when we are alone. As she rides me like a Rari, I tell her woah. But I don't care that you're alone. If only you were here for a day. So I'd let you know you're a jerk.

  3. Voyage & Nucci

    Jednu u BG-u, alu drugu u Luganu. Woah, nosi moje stvari, ti prelepa si, bani. Ti pokaži mi šta radis, kad priđem ti (Woah) Nismo više mali, to kaže kad smo sami. Dok vozi me kô 'rari, ja kažem joj woah. Ali mene briga što si sam. Da si barem tu na dan. Da ti priznam da si gad. Niko ne zna ono sto ti znaš.

  4. Voyage & Nucci

    May 8, 2022. Gad Lyrics - Voyage & Nucci. (Hej Dalmo) E, uh, a, a. Gradom hoda polugola kad partija. Meni leži tama kao tebi svila. "Nisam takva", znam da to je rekla svima. A loži je krivina, kaže "Napravi mi sina". A ja sanjô da vozim Lambo novi (Vroom, vroom)

  5. Tekstovi.net

    Tekst pjesme Voyage - Gad (feat. Nucci): Gradom hoda polugola kad partija, meni lezi tama kao tebi svila, nisam takva, znam da to je rekla svima, a lozi je krivina kaze, napravi mi sina. A ja sanj´o da vozim Lambo novi, (vroom, vroom), njena guza sva u fashion novi, (vroom, vroom), nije mala, njeni su joj strogi, (vroom, vroom). Cujem, kada smo u sobi tako slatku, ja odvedem je na stranu, da ...

  6. NUCCI x VOYAGE

    [Tekst pesme "Gad"][Uvod: Voyage](Hej Dalmo)E, uh, a, a[Strofa 1: Nucci]Gradom hoda polugola kad partijaMeni leži tama kao tebi svila"Nisam takva", znam da t...

  7. VOYAGE X NUCCI

    Kontakt: [email protected]/Download: https://zed.fanlink.to/gadMuzika: Voyage, NucciTekst: Voyage, NucciBeat produced by: Dalmo, Chris FalconeMix...

  8. NUCCI VOYAGE

    napiŠite u komentarima koje pesme Želite da videte u video

  9. Gad

    Provided to YouTube by IDJDigital LimitedGad · Voyage · NucciGad℗ 2022 Generacija ZedReleased on: 2022-05-07Main Artist: VoyageMain Artist: NucciComposer: ...

  10. Voyage

    Listen to Gad by Voyage on Deezer. With music streaming on Deezer you can discover more than 90 million tracks, create your own playlists, and share your favourite tracks with your friends.

  11. Voyage

    Voyage - Gad | Lirika {Tekst pesme "Gad"} Tekst iz isečka {Nucci} Tako slatku, ja odvedem je na stranu Da joj kažem jednu tajnu malu Nekad desi se da jebem dve. Image of Voyage. Edit Image. Voyage biography. Mihajlo Veruović, poznatiji kao Vojaž (Voyage; Beograd, 15. septembar 2001), srpski je treper.

  12. VOYAGE X NUCC

    Stream VOYAGE X NUCC - GAD song from VOYAGE X NUCCI. Release Date: October 25, 2022.

  13. Meaning of Gad by Voyage & Nucci

    Gad. by. Voyage & Nucci. The song "Gad" by Voyage & Nucci explores themes of desire, attraction, and a nonchalant attitude towards relationships. The lyrics depict a narrative of a provocative woman who walks through the city in revealing clothes, attracting attention and interest from those around her. Nucci expresses his fascination with her ...

  14. Voyage & Nucci

    Songtext zu Gad [Uvod: Voyage] (Hej Dalmo) E, uh, a, a [Strofa 1: Nucci] Gradom hoda polugola kad partija Meni leži tama kao tebi svila "Nisam takva", znam da to je rekla svima A loži je krivina, kaže "Napravi mi sina" A ja sanjô da vozim Lambo novi (Vroom, vroom) Njena guza sva u Fashion Novi (Vroom, vroom) Nije mala, njeni su joj strogi (Vroom, vroom) Čujem, kada smo u sobi Tako slatku ...

  15. Voyage

    Jednu u BG-u, alu drugu u Luganu. Woah, nosi moje stvari, ti prelepa si, bani. Ti pokaži mi šta radis, kad priđem ti (Woah) Nismo više mali, to kaže kad smo sami. Dok vozi me kô 'rari, ja kažem joj woah. Ali mene briga što si sam. Da si barem tu na dan. Da ti priznam da si gad. Niko ne zna ono sto ti znaš.

  16. VOYAGE X NUCCI

    Stream VOYAGE X NUCCI - GAD (OFFICIAL VIDEO) by Bojan Vasilic on desktop and mobile. Play over 320 million tracks for free on SoundCloud.

  17. Voyage

    текст песни Gad. Gradom hoda polu gola kad partija. Meni leži tama kao tebi svila. Nisam takva, znam da to je rekla svima. A loži je krivina, kaže napravi mi sina. A ja sanjô da vozim Lambo novi (Vroom, vroom) Njena guza sva u Fashion Novi (Vroom, vroom) Nije mala, njeni su joj strogi (Vroom, vroom) Cujem, kada smo u sobi.

  18. VOYAGE X NUCCI-GAD (AUDIO)

    About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features NFL Sunday Ticket Press Copyright ...

  19. VOYAGE x NUCCI

    Kontakt: [email protected]/Download: https://zed.fanlink.to/balkanMuzika: Voyage, NucciTekst: Voyage, NucciBeat produced by: PopovMix,Master: Pop...

  20. Voyage

    Sometimes I fuck two in a day. One in Belgrade, the other in Lugano. Woah, she's wearing my stuff, you're beautiful, come over. Show me what you can do, when I come close (Woah) We are no longer little, she says when we are alone. As she rides me like a Rari, I tell her woah. But I don't care that you're alone.

  21. Religions

    The outcome of the Nicopolis crusade (1396)—a crushing victory for the Ottoman Turks over a crusader army led by Franco-Burgundian knights—had particularly deep resonances in the Kingdom of France. This was reflected in several contemporary works that lamented and/or criticised the crusaders' defeat. Among these, Philippe de Mézières's Une Epistre lamentable (1397) and Honorat Bovet ...

  22. Gregorian

    Et jamais ne revient. And never come back. Voyage, voyage. Travel Travel) Plus loin que la nuit et le jour, (voyage voyage) Further than the night and the day, (travel, travel) Voyage (voyage) Travel Travel) Dans l'espace inouï de l′amour.

  23. The SIRT3 activator ganoderic acid D regulates airway mucin ...

    Purpose: The expression of MUC5AC, a highly prevalent airway mucin, is regulated by stimulatory factors such as oxidative stress. Ganoderic acid D (GAD) activates mitochondrial deacetylase SIRT3. SIRT3 regulates mitochondrial function through deacetylation of mitochondrial proteins, thereby playing a significant role in alleviating oxidative stress-related diseases.

  24. Voyage

    The Titanic sank on her maiden voyage. "Титаник" затонул во время своего первого плавания. Many people sickened and died on the long voyage. За время этого долгого путешествия многие заболели и умерли. Supplies for the whole voyage were stowed into lockers.